A Simple Method for the Analysis of Buprenorphine and Norbuprenorphine in Human Urine
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چکیده
Buprenorphine (BUP) is a powerful semisynthetic analgesic. The molecular structure of BUP is closely related to that of morphine, yet it has been estimated to be at least 25 times more potent. Initially, it was available for the treatment of both acute and chronic pain (marketed under various trade names including; Temgesic, Buprenex and Subutex). Following administration, BUP is absorbed and metabolised by N-dealkylation to give norbuprenorphine (norBUP).
منابع مشابه
Analysis of buprenorphine, norbuprenorphine, and their glucuronides in urine by liquid chromatography-mass spectrometry.
Buprenorphine is used for the treatment of chronic pain and also in treatment of heroin addiction as an alternative to methadone. As the availability of buprenorphine increases, so does the risk for abuse and the pressure on forensic and clinical laboratories to analyze for it. Buprenorphine and its dealkylated metabolite are excreted in urine, almost exclusively as glucuronides. The aim of the...
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Buprenorphine, which is used in France as a substitution drug for opioid addiction, is widely abused, and several fatal cases have been reported. In order to confirm a recent intoxication or to establish retrospectively chronic abuse, a simple and reliable gas chromatographic-mass spectrometric method was developed and validated for quantitation of buprenorphine and its active metabolite norbup...
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A sensitive, simple and rapid high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed and fully validated for the simultaneous quantification of buprenorphine (BUP) and its N-dealkylated metabolite norbuprenorphine (NBUP) in 200 μL human plasma. Human plasma samples were prepared using liquid-liquid extraction, and then separated on a Shiseido MG C18 (5...
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